Dietary sodium reduction and blood pressure: a dose-response meta-analysis in hypertensive and chronic kidney disease patients.

ABSTRACT:

Background

Hypertension (HTN) is a leading risk factor for cardiovascular disease, and dietary sodium reduction is a cornerstone strategy for blood pressure (BP) control, particularly in vulnerable populations such as individuals with chronic kidney disease (CKD), who often present with HTN. This study aims to quantify the dose-response relationship between changes in sodium intake and changes in BP, through a meta-analysis of recent randomized controlled trials (RCTs) in individuals with CKD and with or without HTN.

Methods

A systematic literature search was conducted in PubMed, Cochrane Central and Embase databases to identify RCTs published since 2000 that evaluated the isolated effect of sodium intake modification on systolic and diastolic. Only trials estimating sodium

SUBMITTER: Iwelomene O 

PROVIDER: S-EPMC12863083 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature