Association between MRI-derived early second trimester placental physiology and birth weight percentiles in pregnancies without ischemic placenta disease (IPD).

ABSTRACT:

Introduction

This study investigated whether placental structure and function, measured using multiparametric MRI (mpMRI) in early second trimester, are associated with birth weight percentiles. We focused on pregnancies without ischemic placental disease (IPD), excluding cases with preeclampsia, fetal growth restriction (FGR), small for gestational age (SGA), or placental abruption. Clinical and pathological moderators were also examined.

Methods

In this prospective single-center cohort, 199 participants were recruited between 2017 and 2019. Placental MRI was performed at two gestational age (GA) windows: 14-16 weeks (w) and 19-24w. Placental volume, perfusion, and oxygenation were quantified and standardized to 16w for the first imaging timepoint and 20w for the second ima

SUBMITTER: Ramirez RO 

PROVIDER: S-EPMC12863204 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature