CYP1A2 Genotype and the Ergogenic Effect of Acute Caffeine Intake on Muscular Strength and Endurance Performance in Trained Individuals.

ABSTRACT: This study examined whether CYP1A2 (rs762551) genotype modulates the acute ergogenic effects of caffeine on muscular strength and endurance performance in resistance-trained men and women. Ninety-four resistance-trained participants (47 females, 47 males; 39 AA, 44 AC, 11 CC) completed a randomized, triple-blind, placebo-controlled, crossover trial. Participants ingested 3 mg/kg of caffeine or placebo before performing standardized bench press and back squat tests. Mean velocity was measured to assess strength performance against different loads (25%-90%) and muscular endurance during a single set performed to failure at 65% 1RM. Data were analyzed using ANCOVA with supplement, genotype, and sex as factors. Caffeine significantly improved strength and endurance performance across condition

SUBMITTER: Montalvo-Alonso JJ 

PROVIDER: S-EPMC12863236 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature