STING Agonist-Loaded Physalis Mottle Virus-like Particles as a Potent Prophylactic for Metastatic Melanoma.

ABSTRACT: Stimulator of interferon genes (STING) agonists have been presented as a compelling cancer therapeutic for many years yet have been unable to break past clinical trials. To date, the best use cases for STING agonists are as intratumoral therapeutics for solid tumors, but in human trials, rapid wash-out and low efficacy hamper success. Systemic administrations of STING agonists have also been explored, but hurdles include enzymatic instability, leading to rapid clearance and immune toxicity. To overcome these challenges, nanoparticle delivery technologies have been proposed, and in the present study, we bioconjugated a STING agonist to the internal cavity of Physalis mottle virus (PhMV)-like nanoparticles (termed PhMV-STG). PhMV-STG demonstrated enhanced and extended interferon activity

SUBMITTER: Simms A 

PROVIDER: S-EPMC12863269 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature