Developmental single-cell atlas of coronary vessel growth and cardiomyocyte interaction in zebrafish.

ABSTRACT: Cardiac morphogenesis requires the intricate coordination of different cell types and molecular cues. Coronary vessel formation is essential for heart development, yet how coronary vessels grow and contribute to ventricular wall formation remains poorly understood. Here, we combine high-resolution imaging and new genetic tools to systematically analyze coronary vasculature development in zebrafish at each millimeter increment from 7 to 30 mm of body length and identify cellular and molecular milestones defining four distinct coronary network developmental stages. Our data show how coronary vessels expand, pattern, specify and act as vascular scaffolds to guide cardiomyocyte growth throughout development. Manipulating coronary network growth by Vegfa signaling perturbation through gain- and

SUBMITTER: Rouf MA 

PROVIDER: S-EPMC12863305 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature