Mild Short-Term Caloric Restriction Induces Coordinated Changes That Promote Lipid Deposition While Maintaining Thermogenesis Capacity in Interscapular Brown Adipose Tissue of Male Rats.

ABSTRACT: Calorie restriction (CR) without malnutrition improves metabolic health, slows the aging process, and prolongs longevity. Brown adipose tissue (BAT), which specializes in burning energy to produce heat, also contributes to metabolic health; however, the effects of CR on BAT function are only partially understood, and even less is known about those exerted by mild CR for a short period of time. We studied the multifaceted relationship between mild short-term CR (15% applied for 2 weeks) and intrascapular BAT (iBAT) in rats and provided insights into the adaptations occurring in the tissue through multiple complementary approaches: histology, mitochondrial respirometry, comprehensive quantitative proteomics, and targeted metabolomics. Our data indicate that mild short-term CR induces structu

SUBMITTER: Panico G 

PROVIDER: S-EPMC12863420 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature