Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques.

ABSTRACT: Cardiovascular and cerebrovascular diseases, often caused by atherosclerosis, are the stern cause of death worldwide, and carotid plaque play a crucial role in the development of these diseases. Tryptophan metabolism is an important pathway involved in the regulation of immune response, inflammation and vascular health. In this study, we analyzed bulk and scRNA data from carotid plaque to investigate the relevance between tryptophan metabolism and plaque formation. We identified 446 differentially expressed genes that are enriched in immune and tryptophan-related pathways. Focusing on tryptophan metabolism, we identified six key tryptophan-related differentially expressed genes: TPH1, MAOB, TDO2, KMO, KYNU, and CYP1B1. Using the six genes, we constructed a logistic regression model with an

SUBMITTER: Jia X 

PROVIDER: S-EPMC12863520 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature