Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis.

ABSTRACT:

Background

The association between adiposity and increased liver cancer risk is well-recognized, yet underlying metabolic mechanisms require elucidation. This study aimed to identify metabolic mediators linking adiposity markers to liver cancer and assess their potential causality using two-sample Mendelian randomization (MR) analysis.

Methods and findings

We conducted a 1:1 matched nested case-control study within a population-based and prospective cohort study-the Shanghai Men's Health Study (SMHS). The SMHS was initiated in 2002-2006, including 61,469 Chinese men aged 40-74 years, and has been followed up for over 20 years. Targeted metabolomic profiling was performed on baseline plasma samples. Associations between seven anthropometric measurements (body mass index [BMI]

SUBMITTER: Li ZY 

PROVIDER: S-EPMC12863527 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature