Mechanical power and short-term mortality in critically ill patients with ARDS on mechanical ventilation: Insights from the MIMIC-IV database.

ABSTRACT: Mechanical power (MP), or an integrated measure of ventilatory stress, has been proposed as an important determinant of ventilator-induced lung injury and clinical outcomes. However, its prognostic significance in patients with acute respiratory distress syndrome (ARDS) remains incompletely understood. We selected adult patients with Berlin ARDS from MIMIC-IV v3.1. Cox proportional hazard regression models were built to explore the relationship between MP quartiles and in-hospital, 28-day, and 90-day mortality, with progressive adjustment for demographics, severity scores, and ventilatory parameters. We also explored model discrimination and calibration, conducted comparative receiver-operating characteristic curves (ROC) and restricted cubic spline (RCS) analyses, and performed Kaplan-Mei

SUBMITTER: Lu Z 

PROVIDER: S-EPMC12863555 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature