Resuscitation with Blood Products Attenuates Endothelial Glycocalyx Shedding but not the Acute Inflammatory Response to Injury in a Military-relevant Preclinical Porcine Model of Traumatic Hemorrhagic Shock.

ABSTRACT: Traumatic injury induces a complex host response, comprising endothelial damage, and simultaneous pro- and anti-inflammatory responses. These may contribute to complications seen in some patients days or weeks later. Although there is ever-increasing evidence showing that resuscitation with blood products improves survival, their impact on the host response remains unclear. A terminally anesthetized Large White pig model of traumatic hemorrhagic shock (THS) and prolonged care evaluated different resuscitation fluids (saline, fresh-frozen plasma, packed red blood cells and fresh-frozen plasma [1:1], or fresh whole blood [n = 9 per group]). Serial blood samples were collected for enzyme-linked immunosorbent assay, hematology, and flow cytometry, and postmortem tissue samples collected for RT

SUBMITTER: Purcell R 

PROVIDER: S-EPMC12863592 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature