The Influence of Sleep Restriction and High-Intensity Interval Exercise on Plasma and Skeletal Muscle Inflammatory Markers in Young Healthy Males.

ABSTRACT:

Purpose

Inadequate sleep has been linked to the development of cardiometabolic disease, with increases in inflammation suggested as a possible underlying mechanism. Exercise has anti-inflammatory properties and may ameliorate some of the detrimental inflammatory effects associated with sleep loss. The present study aimed to investigate the effect of sleep restriction, with or without high-intensity interval exercise (HIIE), on plasma and skeletal muscle markers of inflammation.

Methods

Twenty-four healthy, young males underwent a five-night sleep intervention period. Participants were allocated to one of three groups; Normal Sleep (NS, n=8) (8 h time in bed each night (TIB)), Sleep Restriction (SR, n=8) (4 h TIB), or Sleep Restriction and Exercise (SR+EX, n=8, 4 h TIB, with

SUBMITTER: Saner NJ 

PROVIDER: S-EPMC12863603 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature