Associations between maternal lipid profiles and cardiovascular and metabolic outcomes among children who are HIV-exposed uninfected vs. HIV-unexposed children aged 5-8 years in a South African birth cohort.

ABSTRACT:

Objective

To evaluate the association between maternal gestational lipid biomarkers and cardiometabolic health indicators in children who are HIV-exposed uninfected (CHEU) and HIV-unexposed uninfected children.

Design

Prospective cohort study.

Methods

Our study randomly sampled 260 mother-child pairs from Drakenstein Child Health Study ( N  = 100 CHEU & N  = 160 HIV-unexposed uninfected). Multivariable linear regression were used to assess associations between maternal lipid biomarkers from second trimester of pregnancy with child cardiometabolic indicators at 5-8 years of age and explored potential effect modification by HIV exposure status in stratified analyses. Child cardiometabolic indicators included lipids, glucose metabolism, blood pressure, and body compositi

SUBMITTER: Dogon C 

PROVIDER: S-EPMC12863626 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature