Prevalence and determinants of vascular aging in Austria - a holistic view: the LEAD study.

ABSTRACT:

Objectives

Vascular aging (VA) is a prognostically relevant aspect of biological aging. We investigated its prevalence and determinants in Austria.

Methods

The LEAD (Lung, Heart, Social, Body) study is an ongoing, longitudinal, population-based observational study, which started in 2011 in Vienna and six villages from Lower Austria. Within the study, carotid-femoral pulse wave velocity (cfPWV) was measured using applanation tonometry. Based on a reference population (no history of overt cardiovascular disease, no diabetes, no pharmacological treatment for hypertension or dyslipidemia), sex-, and age-specific Z -scores for cfPWV were calculated. Healthy (HVA), normal (NVA), and early (EVA) vascular aging were defined as cfPWV Z -score <10th, 10th-90th, and >90th percentile, r

SUBMITTER: Azizzadeh M 

PROVIDER: S-EPMC12863628 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature