Polyfluoroalkyl substances and altered glucose homeostasis in adolescents following bariatric surgery.

ABSTRACT:

Objectives

Bariatric surgery is an effective treatment for severe obesity and associated metabolic comorbidities. Exposure to polyfluoroalkyl substance (PFAS) before bariatric surgery may attenuate improvements in glucose metabolism and explain some of the heterogeneity in post-surgery outcomes.

Design

This is an observational cohort study.

Methods

Adolescents (n = 186) enrolled in the Teen-Longitudinal Assessment of Bariatric Surgery study were included. Eight-PFAS congeners were measured in plasma before surgery. Linear and logistic regressions were used to examine cross-sectional associations between log₂-transformed PFAS (ng/mL) and fasting glucose, insulin, hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR)

SUBMITTER: Costello E 

PROVIDER: S-EPMC12863651 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature