Seroprevalence of dengue virus antibodies among multiple species of non-human primates in Senegal suggests that sylvatic dengue virus is maintained in non-primate reservoirs in this region.

ABSTRACT: Dengue virus (DENV) circulates in two distinct transmission cycles: one, termed the sylvatic cycle, is enzootic to canopy-living hosts, including non-human primates and primatophilic mosquitoes, and the other, initiated by spillover from the sylvatic cycle, is endemic to humans and anthropophilic mosquitoes. Transmission dynamics of sylvatic DENV in non-human hosts has not been well characterized, and the identity of reservoir and amplification hosts is still to be determined. We investigated the role of the three common species of monkeys in the Kédougou region of Senegal in the sylvatic transmission cycle of DENV. Longitudinal surveillance of primatophilic mosquitoes in this region dating back to the 1970s revealed that sylvatic DENV-2, the only one of the four DENV serotypes found to ci

SUBMITTER: Cinkovich SC 

PROVIDER: S-EPMC12863672 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature