Incidental genomic findings in large scale research: using the "3-I framework" to reveal policy considerations.

ABSTRACT:

Introduction

Incidental findings (IF) can be yielded in genomic research that analyzes data from healthy participants or patients. The need for clear IF policies grows along with the increase in international genomic research, data collection and sharing efforts. This study aims to inform policy discussions and decisions about IF.

Methods

We interviewed key stakeholders involved in Canadian, European, or international research projects. We used the 3-I framework for interview design and analysis, which distinguishes interests (i.e., agendas), ideas (i.e., values), and institutions (i.e., policy structures, e.g., laws) as factors that impact policy decisions. We integrated the three bioethical principles into this framework: respect for persons, beneficence, and justice.

R

SUBMITTER: Onstwedder SM 

PROVIDER: S-EPMC12863703 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature