Long-term effectiveness on glycemic control of insulin compared to combined oral antidiabetic drugs for initial intensive treatment in newly diagnosed type 2 diabetes: A duplicated target trial.

ABSTRACT: Although both intensive insulin therapy (IIT) and combined oral antidiabetic drugs (COAD) can achieve initial intensive glycemic control, evidence comparing their long-term effectiveness following initial remission remains limited. Therefore, this study aims to compare long-term glycemic control and the risk of drug-free remission failure between IIT and COAD in patients who successfully achieved initial intensive glycemic control. This duplicated target trial utilized a cohort of 60,736 patients with type 2 diabetes from 3 hospitals in South Korea (2001-2024). Patients treated with insulin were assigned to the IIT group, and those receiving metformin combined with other oral antidiabetic drugs to the COAD group. Successful initial intensive treatment was defined as HbA1c <7.0% following t

SUBMITTER: Kim TH 

PROVIDER: S-EPMC12863771 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature