Genetically predicted cerebrospinal fluid metabolite levels and risk of sudden sensorineural hearing loss: A Mendelian randomization study.

ABSTRACT: Sudden sensorineural hearing loss (SSNHL) is an idiopathic condition lacking reliable biomarkers or established causal mechanisms. While systemic metabolic dysregulation has been implicated, the specific role of central nervous system metabolites remains unexplored. We applied a 2-sample Mendelian randomization framework to evaluate the causal influence of cerebrospinal fluid (CSF) metabolites on SSNHL risk. Genetic instruments for 338 metabolites were derived from a European-ancestry genome-wide association study (n = 689), and outcome data came from the FinnGen Consortium (3861 cases; 437,331 controls). Analysis employed inverse-variance weighted regression as the primary method, alongside sensitivity and pleiotropy-robust methods. Inverse-variance weighted analysis identified 20 metabol

SUBMITTER: Xuyu Z 

PROVIDER: S-EPMC12863793 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature