A 5-year Chinese longitudinal case report on the malignant transformation of spinal Paget disease.

ABSTRACT:

Rationale

Paget disease of bone (PDB) is a metabolic disorder typically regarded as benign, yet it carries a <1% risk of malignant transformation into osteosarcoma malignant transformation into osteosarcoma, particularly with spinal involvement. Differentiation from other aggressive spinal lesions can be challenging. In Asian populations, prognostic data on Paget sarcoma are scarce. The significance of dual SQSTM1 and ZNF687 mutations and a rapid alkaline phosphatase (ALP) surge as indicators of malignant transformation remains to be fully elucidated.

Patient concerns

We report a case of spinal Paget sarcoma in a patient with a 5-year history of PDB. The patient presented with progressive symptoms culminating in acute neurological deterioration, including bilateral lower lim

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12863807 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature