Integrative metabolomics and genomics analysis reveals chronic gastritis associated metabolites.

ABSTRACT: Metabolomics plays a crucial role in understanding disease mechanisms by identifying biomarkers that reflect biochemical alterations. In chronic gastritis (CG), these metabolic shifts may serve as key contributors, and their investigation could offer profound insights into the underlying mechanisms of the disease's pathogenesis. We conducted a study with genomic and metabolomic profiling of Han Chinese participants from the Zhejiang Metabolic Syndrome Cohort in Zhoushan, Zhejiang, China. Using liquid chromatography-mass spectrometry, we measured 1912 serum metabolites. Logistic regression analysis was performed to identify metabolites associated with CG. Additionally, we conducted a genome-wide association study to explore genetic determinants of these metabolites, and then applied genetic

SUBMITTER: Xia H 

PROVIDER: S-EPMC12863808 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature