Causal association between chloride intracellular channel protein 5 and Hashimoto thyroiditis: A Mendelian randomization study.

ABSTRACT: This objective was to conduct Mendelian randomization (MR) analysis in order to investigate the potential causal relationship between chloride intracellular channel protein 5 (CLIC5) and Hashimoto thyroiditis (HT). Two separate MR analyses were performed, both using CLIC5 as the exposure variable and HT as the outcome. The first analysis utilized exposure data from genome-wide association study (GWAS) ID: prot-a-584 and outcome data from GWAS ID: ebi-a-GCST90018635. The second analysis used the same exposure data but sourced the outcome from ebi-a-GCST90018855. Four MR methods were applied in both analyses: MR Egger, weighted median, inverse variance weighted, and weighted mode. In both analyses, the inverse variance weighted method produced the most significant results, indicating a posit

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12863814 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature