Causal validation of immune antibody responses and nonalcoholic fatty liver disease: Evidence from Mendelian randomization and meta-analysis.

ABSTRACT: In recent years, an increasing number of observational studies have reported the influence of immunity and antibodies on nonalcoholic fatty liver disease (NAFLD). However, no Mendelian randomization (MR) studies have yet been conducted to investigate the causal relationship in NAFLD. Based on a 2-sample MR framework, this study conducted MR analyses between 46 antibody immune response phenotypes and NAFLD using data from 2 different sources. Subsequently, the primary results from the inverse-variance weighted method were subjected to meta-analysis, and multiple testing correction was applied to the meta-analysis thresholds to ensure result accuracy. Finally, reverse MR analyses were performed to examine potential reverse causality between the antibody immune response phenotypes and NAFLD.

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12863889 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature