Identification of potential drug targets for Alzheimer's disease from genetic insights: A Mendelian randomization study.

ABSTRACT: Alzheimer disease (AD) is a primary neurodegenerative disorder of the brain with an unknown cause and complex pathogenesis. It is the most common form of dementia and poses a significant threat to the health of the aging population worldwide. However, effective pharmacological treatments remain limited. This study employed publicly available genome-wide association study summary statistics, which included 4907 plasma proteins as exposures and AD as the outcome. To explore the causal relationship between plasma proteins and AD, 5 Mendelian randomization (MR) analyses were applied. Heterogeneity in the results was assessed using the Cochrane Q test. Horizontal pleiotropy was evaluated through the MR-Egger intercept test. Sensitivity analysis was conducted using a leave-one-out approach. Plas

SUBMITTER: Zhao YH 

PROVIDER: S-EPMC12863894 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature