Protective effect of new histone deacetylase 6 inhibitors in a cisplatin-induced peripheral neurotoxicity murine model.

ABSTRACT:

Introduction

Histone deacetylase 6 (HDAC6) inhibitors have shown effectiveness in preclinical models of chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of various antineoplastic drugs, with no available preventive or therapeutic treatments. This study presents in vivo results for ITF6464 and ITF6475, 2 HDAC6 inhibitors featuring a difluoromethyloxadiazole (DFMO), zinc-binding group ensuring selectivity for HDAC6.

Objectives

This study investigated the potential effect of 2 new selective DFMO HDAC6 inhibitors in preventive and curative settings in a well-established CIPN model.

Methods

The effectiveness of treatments was evaluated by dynamic test and histological analysis on dorsal root ganglia (DRG) and skin biopsy. The acetylation of tubulin w

SUBMITTER: Cavaletti G 

PROVIDER: S-EPMC12863917 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature