Band-Selective IR PRESS for Brain Tumor Spectroscopy Allows Robust Detection of Lactate.

ABSTRACT: Lactate plays a critical role in the tumor microenvironment, driving tumor progression, metastasis, and immune evasion. Despite its importance, in vivo quantification of lactate using magnetic resonance spectroscopy (MRS) has faced challenges, primarily due to the overlapping lipid signal at 1.3 ppm. Current clinical practice employs a long echo time to exploit differences in T2 relaxation between lactate and lipids; however, this approach significantly suppresses signals from other metabolites. Lipid has a notably different T1 relaxation time than lactate and other metabolites, which may be exploited by an inversion recovery sequence to better distinguish them. However, this method has not found wide use because of the loss of signal in other metabolites. Here, we introduce a selective in

SUBMITTER: Kishimoto S 

PROVIDER: S-EPMC12863986 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature