Pragmatic trial design enhances diversity and retention among research participants with Lewy body diseases.

ABSTRACT: An ongoing pragmatic, randomized, unblinded clinical trial compares pimavanserin and quetiapine for psychosis in Lewy body diseases over 6 months (n = 60). Relative to local explanatory clinical trials, retention is higher (93% vs 40%, p < 0.001) and Hispanic enrollment greater (38% vs 21%, p = 0.043), reflecting the clinic demographics. Embedding pragmatic trials within routine care can enhance retention and diversity, thereby improving representativeness and real-world applicability of clinical research. Registry: ClinicalTrials.gov, TRN: NCT05590637; Registration Date: 18 October 2022.

SUBMITTER: Tran N 

PROVIDER: S-EPMC12864035 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature