Non-linear association between metabolic score for insulin resistance and diabetes mellitus in normal-weight middle-aged and older Chinese adults: a multicenter retrospective cohort study.

ABSTRACT:

Background

Although the link between the metabolic score for insulin resistance (METS-IR) and diabetes mellitus (DM) is well-established in general populations, it remains underexplored in normal-weight middle-aged and old adults-an often-overlooked group in metabolic research. Therefore, this study investigated the association between METS-IR and diabetes in this specific population.

Methods

A retrospective cohort study was conducted using data from the Rich Healthcare Group database, including 23,692 normal-weight (body mass index: 18.5-23.9 kg/m²) Chinese adults aged ≥45 years. Cox proportional hazards models were applied with adjustments for demographic, clinical, and biochemical confounders. Non-linearity was examined using smooth curve fitting and threshold

SUBMITTER: Cai H 

PROVIDER: S-EPMC12864058 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature