Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model.

ABSTRACT:

Background

Currently, the treatment of glaucoma is limited to reducing intraocular pressure since other involved pathomechanisms are not well understood yet. Evidence points to an immune-mediated component in disease development. For example, elevated antibody levels against heat shock protein 27 (HSP27) were detected in glaucoma patients. In mice, we previously noted glaucoma-like damage after an intravitreal HSP27 injection. Now, we aimed to investigate if intermittent fasting protects from this glaucomatous damage.

Methods

CD1 mice were intravitreally injected with HSP27 into one eye. The contralateral eye served as a control. After injections, half of the animals received food ad libitum (no diet). The other half fasted, hence access to food was denied for 24 h at three

SUBMITTER: Maler DL 

PROVIDER: S-EPMC12864140 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature