Sustained soluble adenylyl cyclase (sAC)-generated cAMP is necessary and sufficient for hyperactivated motility in human sperm.

ABSTRACT:

Study question

How does soluble adenylyl cyclase (sAC)-generated cyclic AMP (cAMP) control hyperactivated motility in human sperm?

Summary answer

sAC-generated cAMP rapidly initiates and is required to maintain hyperactivated motility in human sperm.

What is known already

Mouse and human sperm devoid of sAC activity (either genetically or pharmacologically) are immotile and do not undergo capacitation; thus, the HCO3--dependent stimulation of sAC and consequent increase in cAMP is responsible for activating basal motility and initiating capacitation in multiple mammalian species. Among the changes sperm undergo during capacitation is acquisition of hyperactivated motility, which is presumed to be essential for male fertility.

Study design, size, duration

In thi

SUBMITTER: Ritagliati C 

PROVIDER: S-EPMC12864154 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature