Pivotal plasmids drive the global spread of CTX-M-27 in Escherichia coli.

ABSTRACT: The detection rate of CTX-M-27-producing E. coli has increased worldwide in recent years although relatively little is known about the strains and vectors responsible for this increased isolation.To explore the evolution of CTX-M-27-producing E. coli in the past 20 years at three levels; genetic structure of the bla_CTX-M-27 locus, nature of carrying plasmids and types of host bacteria, we analysed 543 genomes of bla_CTX-M-27-positive E. coli isolated globally from 2003 to 2020.Results indicated that hospitalised patients are a major reservoir of bla_CTX-M-27 carrying isolates but there are a wide variety of other resistance genes, plasmid replicons and virulence factors carried by CTX-M-27-producing E. coli strains. There was a strong positive correlation bet

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12864245 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature