In Silico Analysis and Expression Profiling of Adhesin-Like Flocculins in Trichosporon asahii.

ABSTRACT:

Background

Trichosporon asahii is an opportunistic basidiomycetous yeast increasingly recognized as a cause of invasive infections in immunocompromised individuals, often associated with high morbidity and mortality. Its ability to adhere to host tissues and abiotic surfaces is considered a critical virulence factor, yet the molecular mechanisms underlying this adhesion remain poorly understood.

Objective

To characterize gene sequences in T. asahii belonging to the flocculin family with potential adhesive functions.

Methods

The homologous flocculin genes DHA1, DHA2, CPL1, and CFL1, previously described in Cryptococcus neoformans as being involved in cell adhesion, were identified within the T. asahii predicted proteome. Four T. asahii strains were analyzed: two refere

SUBMITTER: Dos Santos MJM 

PROVIDER: S-EPMC12864254 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature