Genotype-phenotype correlations in breast cancer susceptibility: evaluating MMP-2, TYMS, and eNOS variants in the Jordanian population.

ABSTRACT: Breast cancer (BC) is a complex, polygenic, and heterogeneous disease influenced by both genetic and environmental factors. Several genetic polymorphisms, including single nucleotide variants (SNVs) and variable number tandem repeats (VNTRs), have been implicated in BC susceptibility and prognosis across diverse populations. This study aimed to assess the association between genetic variants in the MMP-2, TYMS, and eNOS genes and breast cancer risk in the Jordanian population. A case-control study was conducted involving 300 BC patients and 321 healthy controls. Genotyping was performed using conventional PCR and PCR-RFLP techniques to analyze one SNV in MMP-2 (rs2285053) and two VNTRs in TYMS (rs45445694) and eNOS. The MMP-2 SNV (rs2285053) and TYMS VNTR (rs45445694) showed significant as

SUBMITTER: Alorjani M 

PROVIDER: S-EPMC12864866 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature