Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is the third most diagnosed cancer worldwide and the second leading cause of cancer-related deaths. A major challenge in CRC treatment is drug resistance, which limits the efficacy of conventional therapies. Ferroptosis, an iron-dependent form of regulated cell death driven by the accumulation of reactive oxygen species (ROS), has emerged as a promising therapeutic strategy. Erastin (ER), a small-molecule compound, induces ferroptosis through ROS accumulation.

Methods

We performed microarray gene expression analysis on two CRC cell lines, HCT116 and HT-29, to examine the transcriptional response to ER exposure and identify differentially expressed genes and pathways involved in ER-induced ferroptosis.

Results

Our gene expression an

SUBMITTER: Balik-Meisner M 

PROVIDER: S-EPMC12865207 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature