Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions.

ABSTRACT: Inflammatory diseases, encompassing conditions like inflammatory bowel disease and rheumatoid arthritis, present a significant clinical challenge with substantial treatment-refractory patient populations despite biologic therapy advances. Stem cell therapeutics have emerged as a transformative approach, leveraging multifaceted regenerative mechanisms to address the complex pathophysiology of these conditions, which involves genetic, microbial, immunological, and epithelial dysregulation. This review focuses on comparing the clinical efficacy of contemporary stem cell strategies. We analyze outcomes across diverse cell sources, with a detailed examination of delivery methodologies. Our systematic analysis demonstrates superior efficacy with targeted delivery systems, particularly in managin

SUBMITTER: Wu C 

PROVIDER: S-EPMC12865230 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature