SMARCA4 regulates SMARCAD1 expression for toleration of replication stress in non-small cell lung cancer.

ABSTRACT:

Objectives

SMARCA4, a core component of the SWI/SNF chromatin remodeling complex, is frequently mutated in non-small cell lung cancer (NSCLC). SMARCA4-deficient cancer cells are associated with increased replication stress, one of the major causes of genomic instability, which may lead to cancer. SMARCAD1, a chromatin remodeler, is known as replication fork progressor, and SMARCAD1 dysregulation is also closely related to cancer development. This study aimed to investigate the role of the SMARCA4-SMARCAD1 axis in the toleration of replication stress in NSCLC, focusing on the regulatory relationship between SMARCA4 and SMARCAD1 during replication stress conditions.

Methods

Human NSCLC cell lines (Calu-6, NCI-H1975, Calu-1, and NCI-H460) were used for experiments. SMARCA4 and

SUBMITTER: Sawangsri P 

PROVIDER: S-EPMC12865287 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature