Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA.

ABSTRACT:

Introduction

Little is known about how Alzheimer's disease (AD) plasma biomarkers relate to cerebral small vessel disease (cSVD) neuroimaging biomarkers.

Methods

The study involved 251 Wake Forest Multi-Ethnic Study of Atherosclerosis (MESA) Exam 6 participants with plasma AD biomarkers, magnetic resonance imaging, amyloid positron emission tomography (PET), and adjudicated cognitive status. Multivariable models examined cross-sectional relationships between plasma and neuroimaging biomarkers, considering comorbidities.

Results

Lower amyloid beta (Aβ) 42/Aβ40 and higher glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau at threonine 217 (p-tau217) were associated with greater neurodegeneration. Lower plasma Aβ42/Aβ40 and hi

SUBMITTER: Lockhart SN 

PROVIDER: S-EPMC12865319 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature