Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease.

ABSTRACT:

Introduction

Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD.

Methods

Lipidomics and activity-based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient donors, that is, individuals with AD pathology without cognitive decline.

Results

The most pronounced alterations in lipids were in ω6-derived oxylipins, which were particularly increased in AD. Triacylglycerols (TAGs) and lipid droplets (LDs) were more abundant in the AD donors compared to the resilient donors. Multi-omics factor analysis (MOFA) showed that increased ω6-derived oxylipins and the loss of inhibitory neurons were a

SUBMITTER: van der Vliet D 

PROVIDER: S-EPMC12865325 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature