Cadmium exposure at low environmental levels induces cognitive decline in aged male mice.

ABSTRACT: Cadmium (Cd) is a neurotoxic metal that accumulates via dietary, environmental, and occupational sources and is closely linked to oxidative stress and neuroinflammation. Little is known about the mechanistic effects of low-dose environmental Cd as found in the human diet on cognition in aged mice. Male aged mice (C57BL/6 J, 20 months old) received water with or without 3.3 mg/L Cd for 12 weeks. Cognitive function was assessed using the Y-maze, thiol/disulfide redox states were analyzed by high-performance liquid chromatography, brain Cd levels were determined by inductively coupled plasma mass spectrometry, hippocampal morphology was examined by histological analysis, and metabolomics was analyzed by high-resolution mass spectrometry. Low-dose environmental Cd exposure led to brain Cd accu

SUBMITTER: Lim G 

PROVIDER: S-EPMC12865804 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature