Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study.

ABSTRACT:

Background

To identify blood DNA methylation profiles related to liver steatosis, we performed an EWAS on the presence of ultrasonically-identified liver steatosis in the Young Finns Study (YFS) participants (n = 1529, 33-50y.), and on liver enzyme levels and fatty liver index (FLI) across three discovery cohorts: YFS, LURIC (n = 2371, 17-92y.) and KORA FF4 (n = 1872, 39-88y.). We further investigated the discovered associations across the longitudinal subset of YFS (n = 255), encompassing three follow-ups over 32 years, and the three-generational YFS-3G follow-up in 2018-2020. Finally, we examined the associations of the discovered CpGs with nearby genetic variation and whole blood expression of nearby genes.

Results

In YFS, the methylation levels of cg06690548 (SLC7A11) we

SUBMITTER: Ciantar J 

PROVIDER: S-EPMC12866020 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature