Identification of RPGRIP1L as an instability-maintaining gene to drive tumor growth and PD-L1 expression via Hedgehog signaling in breast cancer.

ABSTRACT: Genomic instability is a hallmark of nearly all human cancers, yet the genetic regulators that govern this instability, their functional roles, and their therapeutic potential remain incompletely understood in breast cancer. In this study, we conducted a comprehensive analysis of the expression profiles of genomic instability-maintaining genes (GIMGs) in breast cancer and revealed that elevated expression of GIMGs was associated with adverse clinical outcomes and an altered tumor immune microenvironment. Through further analysis, we identified a core set of GIMGs and pinpointed RPGRIP1L as a critical driver of genomic instability in breast cancer. Notably, RPGRIP1L expression was significantly upregulated in breast cancer tissues and strongly correlated with poor patient prognosis. Functio

SUBMITTER: Lv M 

PROVIDER: S-EPMC12866045 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature