Restoring immune homeostasis in atherosclerotic plaques via inorganic violet phosphorus nano-immunotherapy.

ABSTRACT: Atherosclerosis is a chronic inflammatory disease driven by immune cell interactions within plaques. Nanotherapeutics targeting immune regulation offer potential for atherosclerosis treatment. However, current nanotherapies mainly focus on modulating individual immune subsets and rarely examine cross-cell anti-atherosclerotic mechanisms. Here, we develop an inorganic nanoparticle platform (PEGylated violet phosphorus nanosheets [VPNS@P]) that efficiently accumulates in the immune microenvironment of atherosclerotic plaques, particularly in macrophages and monocytes and partly T/B cells, with minimal off-target uptake. The VPNS@P platform substantially reduces plaque areas and improves plaque stability in atherosclerotic mice without observed side effects. Importantly, we unravel the underl

SUBMITTER: Zeng W 

PROVIDER: S-EPMC12866099 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature