Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study.

ABSTRACT:

Background

Prostate cancer (PCa) is the second leading cause of death in men and is highly prone to metastasis. This study aims to develop the novel immuno-PET/CT tracer targeting trophoblast cell surface antigen 2 (Trop2), a transmembrane protein overexpressed in aggressive prostate malignancies, and to investigate its diagnostic value in preclinical studies as well as its potential utility in detecting metastases in PCa patients.

Methods

Integrated analysis of TCGA, GEO, and HPA datasets revealed Trop2 overexpression in prostate adenocarcinoma. By labeling two Trop2-targeted nanobodies (His-tagged T4 and His-tag-free RT4) with ⁶⁸Ga and ¹⁸F, we synthesized three radiotracers, [⁶⁸Ga]Ga-NOTA-T4, [¹⁸F]AlF-RESCA-T4, and [¹⁸

SUBMITTER: Long X 

PROVIDER: S-EPMC12866200 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature