Galectin-3 in biliary atresia and other pediatric cholestatic liver diseases.

ABSTRACT:

Aims

Biliary atresia (BA) is characterized by intrahepatic inflammation and rapid progression of liver fibrosis. Galectin-3, a beta-galactoside binding protein, is a key regulator of inflammation and fibrosis. The aim of this study was to characterize circulating and hepatic Galectin-3 levels in children with BA.

Methods

Plasma and liver samples were obtained from children with early BA at time of Kasai hepatoportoenterostomy, late BA at time of transplant, early and late other cholestatic liver diseases (CLD), and controls. Plasma Galectin-3 was measured using standard enzyme-linked immunoassay. Liver tissue was analyzed with multiplex immunohistochemistry and quantified using whole slide analysis. Statistical comparisons were made using nonparametric testing.

Results

SUBMITTER: Yoeli D 

PROVIDER: S-EPMC12866417 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature