Novel insights into meningioma brain invasion with spatial transcriptomic profiling.

ABSTRACT: Brain invasion of meningioma is a controversial clinicopathological grading criterion that correlates with prognosis and is a stand-alone criterion for WHO grade 2 meningioma. Molecular correlates of meningioma cells and immune cell infiltration at the brain-meningioma border and its possible role in brain invasion are not known. We hypothesized that brain-invasive meningiomas have distinct gene expression profiles in meningioma cell populations and in tumour-associated microglia and macrophages (TAM) populations, most prominently at the brain-meningioma border.We performed spatial transcriptomics using NanoString GeoMx Digital Spatial Profiling to investigate the gene expression profiles of meningioma cell-enriched populations (Iba1-/CD68-) and TAM-enriched populations (Iba1+/CD68+) acros

SUBMITTER: Maier AD 

PROVIDER: S-EPMC12866443 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature