Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum.

ABSTRACT:

Background

Malaria is a deadly parasitic disease for which innovative treatments are urgently needed. A mixture of eight triterpenic esters (8TTE) was previously identified as important for the antiplasmodial activity of Keetia leucantha twigs, a plant used in traditional medicine in Benin. Despite the reported in vitro and in vivo activity, the targets of 8TTE are unknown.

Methods

The present study investigated the mode of action of 8TTE on Plasmodium falciparum by a multi-scale integrative study from phenotype to metabolome, including: phenotypic analysis, enzymatic tests, molecular docking and metabolomic profiling.

Results

This study identified a unique antiplasmodial profile with activity onset in the early-ring stage of the parasite, the inhibition of aminopepti

SUBMITTER: Mamede L 

PROVIDER: S-EPMC12866511 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature