Dataset Information
BAP1-mediated stabilization of SUFU enhances E2F1 activity and promotes colorectal tumorigenesis.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC12866594 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
BAP1-mediated stabilization of SUFU enhances E2F1 activity and promotes colorectal tumorigenesis.
Cell communication and signaling : CCS 20260103 1
BACKGROUND: The Hedgehog (Hh) signaling pathway plays a pivotal role in tumorigenesis. SUFU (Suppressor of Fused), a key negative regulator of Hh signaling, also interacts with additional signaling pathways involved in cancer progression. However, its specific function and regulatory mechanisms in colorectal cancer (CRC) remain poorly understood. METHODS: Using Co-immunoprecipitation (Co-IP), we identified BAP1 as a candidate deubiquitinating enzyme (DUB) that interacts with SUFU. Western blotti ...[more]