Integrative Multi-Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer.

ABSTRACT: Current understanding of immune characteristics in gastric cancer remains limited for guiding clinical practice, particularly immunotherapy. This study aims to elucidate the multidimensional landscape of tumor microenvironment in gastric cancer, identify predictive biomarkers potentially associated with favorable immunotherapy response, and propose a precision stratification framework to inform therapeutic strategies. This study introduces a novel immune classification system tumor immune microenvironment (TIME)-inflamed, TIME-desert, and TIME-excluded), and characterize the cellular and molecular characteristics of each subtype. TIME-inflamed tumors exhibit significantly higher infiltration of immune cells in tumor regions, as well as increased expression of inflamed-genes. TIME-desert tu

SUBMITTER: Wang J 

PROVIDER: S-EPMC12866680 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature