The Pivotal Role of GR-CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood.

ABSTRACT: Multiple prenatal adverse environmental factors alter hepatic cytochrome P450 (CYP) enzymes expression in offspring, with these changes persisting after birth. These factors induce fetal exposure to excessive maternal glucocorticoids (GCs), however, the mechanisms by which intrauterine GCs exposure programs offspring CYP expression remain unclear. Given that GCs are high-affinity ligands for the glucocorticoid receptor (GR), this work employs dexamethasone (DEX), a GR agonist, to establish a prenatal dexamethasone exposure (PDE) model for investigating the role of GR activation in CYPs programming. The model is implemented to pregnant Wistar rats and heterozygous liver-specific GR knockout mice. Results show that PDE consistently increases the expression of hepatic CYP3A1 and CYP2B1, there

SUBMITTER: Sun X 

PROVIDER: S-EPMC12866823 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature