Nitric oxide-releasing dextran surface with enhanced albumin affinity mitigates infection and foreign body reaction.

ABSTRACT: Medical device surfaces often lack the blood compatibility and features of native endothelium, leading to issues from blood-material interactions and infection. Procoagulant plasma proteins rapidly adsorb to these surfaces, triggering the coagulation cascade. Concurrently, bacteria may adhere to these foreign surfaces, developing biofilms. To address these issues, we developed a hybrid nitric oxide (NO)-releasing material by integrating the NO donor S-nitroso-N-acetylpenicillamine into polydimethylsiloxane (PDMS), followed by its surface functionalization with blue dextran (NOBD). Blue dextran preferentially binds albumin, reducing adsorption of other plasma proteins as well as its selective displacement, thereby minimizing coagulation cascade activation. Simultaneously, NO release inhibit

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12866958 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature