Predictors of Abnormal Diffusing Capacity for Carbon Monoxide in Post-Pneumonia Ugandans with and without HIV.

ABSTRACT:

Background

Abnormal diffusing capacity for carbon monoxide (DLco) is highly prevalent among people with HIV (PWH) and associated with increased mortality both in PWH and the general population. As there are no DLco data from East Africa, we characterized the prevalence and risk factors for abnormal DLco in PWH and people without HIV (PWoH) in Uganda.

Setting

Kampala, Uganda.

Methods

We performed a cross-sectional analysis of adults with and without HIV, who were followed longitudinally for lung function change after pneumonia. We used the participants' first ATS/ERS-compliant DLco measurements post-pneumonia. We built multivariable linear and logistic regression models to determine predictors of abnormal DLco. We then developed stratified multivariable models to deter

SUBMITTER: Byanova KL 

PROVIDER: S-EPMC12867093 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature